The CUNY School of Public Health and New York City Health Department recently announced that they are conducting the second New York City Health and Nutrition Examination Survey (NYC HANES). From now until early next year, adults from 3,000 randomly selected NYC households will be asked to answer survey questions and take a physical exam that will provide a picture of the city’s health almost 10 years after the first NYC HANES. Funded by the de Beaumont Foundation, the survey enables researchers to examine changes in New Yorkers’ health over two points in time and assess the impact of several health policies that have occurred since 2004. This collaboration also aims to compare NYC HANES population health indicators to data collected through a large distributed electronic health record (EHR) network in NYC – the Primary Care Information Project (PCIP) system. By creating and then validating surveillance estimates using actual large-volume EHR data in a defined geographic region against a gold standard, this project will advance prospects for using EHRs to monitor the health of populations throughout the country.