The U.S. Global Change Research Program (USGCRP) and Interagency Crosscutting Group on Climate Change and Human Health (CCHHG) are announcing opportunities to inform the Interagency Special Report on the Impacts of Climate Change on Human Health in the United States. The Special Report is featured in the President’s Climate Action Plan and will be an evidence-based, quantitative, peer-reviewed assessment of observed and projected climate change impacts on human health in the United States. The report will ultimately be used to inform public health authorities, other planning and policy entities, and the general public.